Development of new processing method for hemp extract for cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) production
Yongseong Han1,2,‡, Dong-Young Woo1,3,‡, Jiyool Kim1,2, Young-Joo Kim1, Jin-Chul Kim1,2, Young-Tae Park1,2, Jung Ho Song4, Jeong Kook Kim4, Taejung Kim1,2,*, and Jungyeob Ham1,2,4,*
1Institute of Natural Products, Korea Institute of Science and Technology (KIST), 2Natural Products Applied Science, University of Science and Technology (UST), 3Department of Chemistry and Advanced Materials, Gangneung-Wonju National University, 4NeoCannBio Ltd.
Correspondence to: *Taejung Kim
Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung, 25451, Korea
Tel: +82-33-650-3607
Fax: +82-33-650-3508
E-mail: kgsing@kist.re.kr
Jungyeob Ham
Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung, 25451, Korea
Tel: +82-33-650-3502
Fax: +82-33-650-3508
E-mail: ham0606@kist.re.kr
‡These authors are contributed equally in this work.
Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung, 25451, Korea
Tel: +82-33-650-3607
Fax: +82-33-650-3508
E-mail: kgsing@kist.re.kr
Jungyeob Ham
Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung, 25451, Korea
Tel: +82-33-650-3502
Fax: +82-33-650-3508
E-mail: ham0606@kist.re.kr
‡These authors are contributed equally in this work.
Received October 30, 2024; Revised November 16, 2024; Accepted November 18, 2024.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Abstract
- The global industrial hemp market is rapidly expanding, driven by the growing demand for cannabinoids such as CBD and THC, highlighting the need for efficient production technologies. This study optimized CBD and THC production by combining dielectric heating-based microwave technology with a continuous process. For CBD production via CBDA decarboxylation in hemp extracts, the continuous process achieved a higher yield (92.8%) under milder conditions (90°C for 30 min) compared to the batch process (90.3% at 120°C for 30 min). Similarly, for THC production via CBD cyclization in hemp extracts, the continuous process yielded 70.5% under shorter reaction times (80°C for 10 min with HCl) compared to 62.1% in the batch process (80°C for 20 min with p-toluenesulfonic acid). These results demonstrate that continuous microwave processing is an efficient and scalable technology for cannabinoid production, supporting the growth of the global industrial hemp market.
- Keywords : industrial hemp, cannabinoids, cannabidiol, Δ9-tetrahydrocannabinol, microwave
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