Myungsuk Kim1,*
1Center for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST)
Correspondence to: *Myungsuk Kim
Center for Natural Product Efficacy Optimization, Korea Institute of Science and Technology, Gangneung Institute of Natural Products, 679 Saimdang-Ro, Gangneung, Gangwon-do, 25451, Korea
Tel: +82-33-650-3659
E-mail: g-sstainer@kist.re.kr
Center for Natural Product Efficacy Optimization, Korea Institute of Science and Technology, Gangneung Institute of Natural Products, 679 Saimdang-Ro, Gangneung, Gangwon-do, 25451, Korea
Tel: +82-33-650-3659
E-mail: g-sstainer@kist.re.kr
Received November 4, 2024; Revised December 16, 2024; Accepted December 17, 2024.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Abstract
- Sarcopenia, characterized by age-related loss of muscle mass and function, significantly diminishes quality of life. While the exact pathogenesis remains elusive, a combination of aging, malnutrition, and physical inactivity is implicated. This review systematically evaluated the potential of natural products to prevent and treat sarcopenia. The results revealed that various natural compounds, including curcumin, resveratrol, and catechin, have demonstrated promising effects on mitigating sarcopenia by increasing muscle mass, grip strength, and mitochondrial function. Preclinical studies have elucidated the underlying mechanisms, such as stimulating muscle protein synthesis and inhibiting protein degradation. Clinical trials have also shown some natural compounds can slow down the rate of muscle loss and improve physical function, although long-term efficacy and safety require further investigation. In conclusion, natural products represent a promising therapeutic strategy for sarcopenia prevention and treatment. Systematic studies on the efficacy and safety of individual compounds are needed to develop personalized treatment approaches.
- Keywords : sarcopenia, natural product, muscle mass, grip strength, mitochondrial function
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